AAV-SaCas9在体敲除技术服务
HANHENGSHENGWUJISHUGONGCHENGSHIYUNYONGCRISPR/Cas9JIYINQIAOCHUJISHU,JIANGXIANXIANGGUANBINGDUYUSaCas9JIEHE,JIAAV-SaCas9,KEYISHIXIANGAOXIAOZAITIJIYINQIAOCHU,YESHIZUIXINZUILINGXIANDEZAITIJIYINQIAOCHUJISHU。 YULEJIEAAVBUTONGDEXUEQINGXINGJIDIDUQINGZIXUNQUANGUOMIANFEIFUWUREXIAN:400-092-0065
AAV其他相关特色服务
AAV-SaCas9简介
ZUIZAOZAIXIJUNZHONGBEIFAXIAN,CRISPR-Cas9XITONGNENGGOUQIEGEDNA,CHONGDANGLEDUIKANGBINGDUGANRANDEYIGEZHONGYAOFANGYUJIZHI。JINGUANXUDUODEWEISHENGWUWUZHONGDOUYONGYOUZHEIYIXITONG,YANJIURENYUANYOUXIANXUANZEGAIZAOLELAIZIHUANONGLIANQIUJUNDECas9MEI(SpCas9)LAIGAIBIANGAODENGSHENGWUDEDNA,BINGYICHENGWEIYIXILIEGAODUTONGYONGDEJIYINZUXIUSHIJISHUDEJICHU。
YAOXIANGRAOLUANCHENGTIDONGWUZHONGDEJIYIN,BIXUYAOLIYONGYIXIEZAITIJIANGCRISPR-Cas9XITONGDEGUANJIANYUANJIANDAORUDAOXIBAOZHONG。YOUYUBUHUIYINQIRENLEIJIBINGBINGYIZAIOUZHOUHUODELINCHUANGJIANGUANJIGOUDEPIZHUN,XIANXIANGGUANBINGDU(AAV)BEISHIWEISHIZUIYOUQIANJINGDEHOUXUANZAITIZHIYI。RANER,AAVWEIXIAODEFUZAINENGLISHIDETONGSHIBAOZHUANGSpCas9MEIHEQITAJIYINBIANJIBIXUDEYUANJIANJINRUDAODANGEBINGDUKELIZHONGCHENGWEIYIGETIAOZHAN。
MASHENGLIGONGDEKEXUEJIAZHANGFENGYANJIUYUANZUIXINDEYANJIUFAXIANYIZHONGLAIZIJINHUANGSEPUTAOQIUJUNDECas9HESUANMEI(SaCas9),TABISpCas9XIAO25%,ZAIAAVBINGDUDEBAOZHUANGRONGLIANGFANWEIZHINEI,CONGERWEIAAVDEBAOZHUANGWENTITIGONGLEYIGEJIEJUEFANGAN。
2015 Apr 9;520(7546):186-91
汉恒生物技术工程师运用CRISPR/Cas9基因敲除技术,将腺相关病毒与SaCas9结合,即AAV-SaCas9,可以实现高效在体基因敲除,也是最新最领先的在体基因敲除技术。并且可以根据动物靶器官,选择不同血清型的AAV(不同血清型AAV对各组织器官的亲和性见下表),是目前最有效的在体基因敲除技术。
AAV载体不同血清型
YANJIUFAXIAN AAV JUYOUDUOZHONGXUEQINGXING,GEZHONGBUTONGXUEQINGXINGDE AAV ZAITIDEZHUYAOQUBIESHIYIQIAODANBAIBUTONG,YINCIDUIBUTONGDEZUZHIHEXIBAODEZHUANRANXIAOLVCUNZAICHAYI。MUQIANHANHENGSHENGWUZAIBAOZHUANGXIANXIANGGUANBINGDUSHIYOU12 ZHONGBUTONGDE AAV XUEQINGXINGKEGONGKEHUXUANZE,JIANYIKEHUZHENDUIBUTONGZUZHIQIGUANXUANZEXIANGYINGXUEQINGXINGDE AAV BINGDU,JIANBIAO 1。
BIAO1.12ZHONGBUTONGXUEQINGXINGAAVDUIGEZUZHIQIGUANXIBAODEQINHEXING
AAV-SaCas9服务流程
参考文献
1、Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear; (2016年发表于Nature Neuroscience,作者:段树民) 2、LRP6 acts as a scaffold protein in cardiac gap junction assembly; (2016年发表于Nature Communications,作者:陈义汉) 3、Characterization of fowl adenovirus serotype 4 circulating in chickens in China; (2019年发表于Vet microbiology,作者:fanghua wei) 4、Long noncoding RNA HIF1A-AS2 facilitates cell survival and migration by sponging miR-33b-5p to modulate SIRT6 expression in osteosarcoma ; (2019年发表于Biochem Cell Biology,作者:赵政旭) 5、Expression levels of microRNAs that are potential cytochrome P450 regulators in cynomolgus macaques; ,作者:Uno Y)
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