环状RNA简介

 

circRNAs（Circular RNAs，HUANXINGRNAFENZI）SHIYILEIBUJUYOU5' MODUANMAOZIHE3' MODUANpoly(A)WEIBA、BINGYIGONGJIAJIANXINGCHENGHUANXINGJIEGOUDEFEIBIANMARNAFENZI。circRNASHIQUBIEYUCHUANTONGXIANXINGRNADEYILEIXINXINGRNA，JUYOUBIHEHUANZHUANGJIEGOU，DALIANGCUNZAIYUZHENHEZHUANLUZUZHONG。DABUFENDEHUANZHUANGRNASHIYOUWAIXIANZIXULIEGOUCHENG，ZAIBUTONGDEWUZHONGZHONGJUYOUBAOSHOUXING，TONGSHICUNZAIZUZHIJIBUTONGFAYUJIEDUANDEBIAODATEYIXING。YOUYUHUANZHUANGRNADUIHESUANMEIBUMINGAN，SUOYIBIXIANXINGRNAGENGWEIWENDING，ZHEISHIDEHUANZHUANGRNAZAIZUOWEIXINXINGLINCHUANGZHENDUANBIAOJIWUDEKAIFAYINGYONGSHANGJUYOUMINGXIANYOUSHI。

 

HANHENGSHENGWUWEIBIAODAHUANZHUANGRNAZAIMANBINGDU（Lentivirus）、XIANBINGDU（Adenovirus）HEXIANXIANGGUANBINGDU(Adeno associated virus)DENGGONGJUBINGDUZAITISHANGYINRUDUJIAYANFADEJIYINHUANHUABIAODAKUANGJIA，SHIHUANZHUANGRNALIANRUZAITIHOUNENGZAITIWAIGAOXIAOLVBIAODA，BINGBAOZHENGCHARUDEMUDEHUANZHUANGRNAPIANDUANZHENGQUEHUANHUA。

 

 

环状RNA的类型

 

 

 

 

 

TU1. TONGYIJIYINWEIZHIKEYICHANSHENGBUTONGLEIXINGDEHUANZHUANGRNA

 

 

汉恒circRNA QPCR引物

         

HANHENGTUANDUIYONGYOUZUICHENGSHUDEcircRNAYINWUSHEJIYUcircRNA-QPCRYANZHENGJISHU，QUFENCHENGHUANYUWEICHENGHUANRNA。 

 

 

环状RNA的功能

 

1. HUANZHUANGRNAKEYIZUOWEI“sponge”HAIMIANXIFUmiRNA，YIZHIQIGONGNENG

2. circRNATONGGUOJIANJIHUBUPEIDUIZHIJIEDIAOKONGQITARNASHUIPING

3. circRNANENGYUDANBAIZHIJIEHE，YIZHIDANBAIZHIHUOXING、MUJIDANBAIZHIFUHETIDEZUFENHUODIAOKONGDANBAIZHIDEHUOXING

 

 

汉恒提供环状RNA病毒包装服务

 

 

 

 

环状RNA病毒载体构建服务

 

 

pHBAd-ciRHUANZHUANGRNAXIANBINGDUZAITI

 

 

 

pHBAd-ciRHUANZHUANGRNAMANBINGDUZAITI

 

 

 

 

pHBAd-ciRHUANZHUANGRNAXIANXIANGGUANBINGDUZAITI

 

 

汉恒研究中心研究人员为您提供多种circRNA研究工具与解决方案

 

circRNA功能与重要性越来越受到重视，不管是生理、病理还是biomarker。汉恒生物经验丰富的circRNA研究团队，为您提供circRNA研究工具，参与定制您的项目解决方案。

 

 

参考文献

 

1、Role of the microRNA, miR‐206, and its target PIK3C2α in endothelial progenitor cell function–potential link with coronary artery disease；

 （2015年发表于FEBS J.，作者：Xie Y）

 

2、A novel role of microRNA 17-5p in the modulation of circadian rhythm；

 （2016年发表于Sci Rep，作者：Ji-Min Cao）